When some tissue injury occurs histamine and other vasoactive substances (called mediators of inflammation) are released, they cause vasodilation and the blood flow to the affected site increases. Granulocyte leukocytes present in the blood are attracted to the site of the injury by substances known as chemotactic factors also released by the injured tissue and by the active granulocytes in the area. The granulocytes exit the capillaries by diapedesis, i.e., using pseudopods. Macrophages present in the region are activated too. These cells flood the extracellular space of the affected area trying to kill or eliminate harmful agents, to prevent tissue necrosis and to isolate the damaged tissue.