Why do protease- supplying cells of the stomach and of the pancreas make only precursors of the active proteolytic enzymes?

11 months ago

The stomach and the pancreas make zymogens of the proteases pepsin, chymotrypsin and trypsin and these zymogens are released into the gastric or duodenal lumen for activation. This happens to prevent the digestion of these organs' (stomach and pancreas) own cells and tissues by the active form of the enzymes. So the production of zymogens is a protective strategy against the natural effects of the proteolytic enzymes.

Dipti KC
May 24, 2023
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